Sentence examples for elevated expression associated from inspiring English sources

In a preclinical study of ERα-positive breast cancer patients, PELP1 expression was identified as an independent prognostic biomarker in assessing clinical outcome; elevated expression associated positively with poor prognosis [ 17].

Although the impact of intron retentions has been less acknowledged, a recent report suggests that intron retention is one of the most predominant splice events in three breast cancer subtypes [ 13], and the retention of intron 4 in the wild-type cholecystokinin type 2 (CCK 2 ) receptor shows elevated expression associated with increased tumor growth in a few cancers [ 14].

It is highly expressed in various metastatic tumor cells and its elevated expression is associated with the poor prognosis of different types of human cancers [ 2– 7].

GSA-Tumor analysis of CCNB1 gene expression shows, in agreement with previous protein-based studies, that elevated expression is associated with the basal-like and luminal B gene expression subgroups (Figure 2A), higher histological grade (Figure 2B), and worse clinical outcome predominantly in ER-positive breast cancers (Figures 2C and D) supported by multivariate analysis (Figure 2E) [32] [34].

The elevated expression is associated with poorer overall survival.

To assess the clinical relevance of these genes, we investigated whether their elevated expression was associated with specific parameters of prostate cancer progression in the Oncomine database [ 31].

Hsp27 is now well described to counteract apoptosis and its elevated expression is associated with increased aggressiveness of several primary tumours.

Thus, ATF4 activates genes that promote restoration of normal ER function and survival, and its elevated expression is associated with resistance to current therapeutic agents including DNA interacting and damaging drugs and proteasome inhibitors.

As 14-3-3ζ 14-3-3ζ 14-3-3ζd is breast cancers with a poverexpressed, and ins elevated expression is associated with activation of growth factor and mitogenic signaling pathways and with endocrine resistance, our data imply that 14-3-3ζ should serve as a marker of resistance and a key therapeutic target for endocrine therapy sensitization and effective tumor suppression.

There are several reports of elevated SR protein family expression associated with ovarian cancer [ 38] and SF2/ASF, specifically, has been described as a proto-oncogene [ 39].

Several studies suggested that high MALAT1 expression is associated with poor prognosis in non-small cell lung cancer (NSCLC), whose elevated expression is also associated with cellular hyper-proliferation (29, 30).