Yet the increases in genes involved in thermogenesis in our study suggest that in addition to the increased fat oxidation, increased heat production could play a role in the elevated energy expenditure in the EPO transfected mice.
The outcome of these investigations could be attributed to the observation that propionate promotes sympathetic activity via FFAR3, resulting in elevated energy expenditure.
The elevated energy expenditure following burn and/or administration of CL316,243 was supported by the significant decrease in eWAT adipocyte sizes.
However, the difference in body temperature is very moderate (0.4 C) and therefore not detectable by an elevated energy expenditure, as we recently determined for the Abcg1−/− mouse.
We conclude that subcutaneous fat remodeling and browning represent an underlying mechanism that explains the elevated energy expenditure in burn-induced hypermetabolism.
Mice treated with Anti-ASP showed elevated energy expenditure (P < 0.0001), increased skeletal muscle glucose oxidation (+141%, P < 0.001), reduced liver glycogen (-34%, P < 0.05) and glucose-6-phosphate content (-64%, P = 0.08) compared to control mice.
98 These findings support the hypothesis that elevated energy expenditure due to SPA-promoting agents such as OXA and defense from SPA-dampening treatments protects against excessive adiposity gain in OR rats.
Global and fat-specific Alk7 knock-out enhanced adipose β-AR expression, β-adrenergic signaling, mitochondrial biogenesis, lipid oxidation, and lipolysis under a high fat diet, leading to elevated energy expenditure, decreased fat mass, and resistance to diet-induced obesity.
To assess whether elevated resting energy expenditure (REE) in female patients with cystic fibrosis (CF) persists longitudinally during late childhood and puberty.
Cachexia is a wasting syndrome associated with elevated basal energy expenditure and loss of adipose and muscle tissues.
Subsequently, pancreatic cancer patients often have an elevated resting energy expenditure (REE) [ 21].
