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While large pore sizes guarantee elevated drug dosages, large fractal dimensions boost cell adhesion on a surface.
CSCs may be resistant to the effect of these agents through their elevated drug resistance or relative quiescence [28].
Regarding frailty, multimorbidity, BMI, and elevated drug intake, no significant differences between men and women could be found.
The primary mechanism underlying this observation appears to be significantly elevated drug CL in parallel with higher CLCR in some patients.
We calculated 3 models: the unadjusted model included the respective gait parameter only, model 1 included in addition BMI, disability, and frailty status as confounders and model 2 which additionally to model 1 included elevated drug intake and multimorbidity as confounders.
Unfortunately, the incidence of toxicity is high and is related to elevated drug exposure.
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Unique drug combination nanoparticles (DcNPs) composed of three HIV drugs lopinavir, ritonavir, and tenofovir have been shown to provide enhanced drug levels in lymph nodes; and elevated drug-combination levels in HIV-host cells in the blood and plasma for two weeks.
7) Encourage a mass culture that spits on intelligence and study and instead elevates drug use, coolness through sex and violence, and contempt for school.
Compared with nanocarrier-based strategies that focus on the loading rate of specified drug molecules to specified nanocarriers, active motions of nanomotors accelerate the thrombolysis by elevating drug transport through a hydrodynamic convection, which is controlled by many parameters such as nanorod concentration, magnetic field, and frequency.
Cytotoxicity was monitored and found to be elevated following drug treatment, which subsequently receded as growth was continued in drug-free media (Additional File 2: Figure S2).
FGF23 levels was suppressed during the periods of drug exposure attributed to direct inhibition of FGF23 release from the bone and elevated upon drug withdrawal driven by increased plasma phosphate and vitamin D levels acting on bone to stimulate FGF23 production [ 182].
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