Sentence examples for elevated checkpoint from inspiring English sources

To test whether the enhanced differentiation observed in Ras cells depends on the elevated checkpoint activity in response to cytarabine, we incubated control and Ras cells for 24 hours with cytarabine in the presence or absence of caffeine, an inhibitor of the Atm and Atr kinases [34].

Half crossover products are also elevated in checkpoint mutants in agreement with the role of the DNA damage checkpoint in suppressing activation of structure-selective nucleases (Vasan et al. 2014).

Importantly, inducing cellular differentiation by withdrawal of 4-hydroxy-tamoxifen and subsequent inactivation of the MLL-ENL-ER chimeric protein did not elevate checkpoint activation in the absence of oncogenic RAS (Figure S8), suggesting that the effects of oncogenic Ras on checkpoint activity are upstream and independent of its effects on cellular differentiation.

In theory these activities can be quickly elevated with the weakening of checkpoint signals, leading to further deactivation of checkpoint signals, and eventually mitotic reentry.

Overall, there is increased resistance for apoptosis; increased cell migration activity; impaired cell protection ability; compromised cell cycle checkpoint machinery, and elevated inflammatory status.

Results also showed that knockdown of FAS elevated genes involved in the G2 pathway including the checkpoint regulators CHEK2, WEE1 and PLK1 (Table 1; Figure 3).

The replicative stress response (RSR), which is characterized by Ataxia telangiectasia mutated rad3 related kinase-Checkpoint kinase 1 (ATR-Chk1) signaling, is elevated in numerous cancer cell types.

Levels of p53, Bax, Securin and p65 in esophageal and stomach cells were elevated during early days of RAN exposure while those of different mitotic checkpoint proteins were downregulated.

Furthermore, the levels of the Matrix metalloproteinase 1 (MMP1) [ 33] were elevated at the basal side of the epithelium showing that, similarly to checkpoint aneuploid mutants, inhibition of apoptosis leads to the activation of MMP1 expression [ 24].

Elevated p53 observed in mutant ES cells might reflect the activation of such checkpoint, if present in ES cells.

IGF1 pretreated mice receiving radiation also have elevated levels of phosphorylated cdc2 (Tyr) and decreased levels of the phosphatase cdc25A, all of which indicate checkpoint activation.