Sentence examples for elements which bind from inspiring English sources

We introduce the concept of dualsteric ligands that consist of distinct elements which bind to each of the orthosteric and an allosteric domain on a single receptor to enhance subtype selectivity.

Multiple ACGT motifs have been shown to form enhancer elements which bind synergistically to transcription factors for gene regulation [ 40].

To date, many PRC1 target genes have been identified including homeobox (HOX) genes and p16 INK4a, whose promoters contain interactive elements which bind directly to Bmi1[ 12].

However, nearly all of the binding energy was contributed by the IST1 MIM1 element, which bound ULK3 MIT2.

Each mRNA sequence starts with a cis-regulatory element which is used as binding site that regulates the activation of the protein, followed by a parameter sequence, which in turn is followed by a trans-acting element which binds to other cis-regulatory elements to control their expression and activation; all represent the translated protein.

TBP is a ubiquitously expressed general transcription factor which binds to a promoter element called the TATA box.

NRF2 is a transcription factor which binds to the antioxidant response element in the promoter of NRF2 regulated genes [32].

The induction of the CPT1B gene occurs via the fatty acid response element (FARE) or peroxisome proliferator-activated receptor (PPAR) response elements (PPREs), which bind the transcription factor PPAR [ 41, 45].

Moreover, introns are a rich resource of regulatory elements, which can bind to diverse RBPs (RNA-binding proteins).

A manner to retain the first intermediate in the splicing compartment could be achieved by introducing intronic elements which could bind elements of the splicing machinery, such as DISE motives, thus signaling that splicing is not yet achieved.

Franchimont et al. showed increased IL-10 levels using low concentrations of dexamethasone and decreased IL-10 levels to below baseline with higher doses of dexamethasone [52] The IL-10 promoter contains cAMP-responsive elements, which are bound by cAMP responsive element binding (CREB) protein, and myocyte enhancer factor (MEF -2 binding sites.