In part, this reflects the selection of P-elements that disrupt essential genes, increasing the probability of impinging on critical pathways.
Each stock contains one P element that disrupts the expression of a gene and causes recessive lethality.
The majority of children identified conflicts, caused by disagreement and dominance, as an element that disrupted play.
Strikingly, these defects are reminiscent of phenotypes associated with eyeless mutations that disrupt an eye-specific regulatory element of the eyeless (ey) gene [38], suggesting that B52 Over-expression may alter ey expression.
The main external causes are lack of opportunities, discrimination, liquidity constraints, barriers to increasing human capital and so forth; there are numerous of papers on this topic.28 There are also several internal causes, such as the Cultural Factor analyzed in this paper, which is obviously an element that disrupts trade and hinders economic growth.
Our observations indicate that most ubiquitin mutations that disrupt E1 activation also disrupt other functions.
For most of the films on Scott's list, the decision not to disrupt the urbane conventions of naturalism goes together with an unwillingness to endow characters or stories with elements that may disrupt the programmatic sympathies the filmmakers are arousing.
The goal, evidently, is to remove any elements that might "disrupt order," with the understanding that any social instability could jeopardize the Party's hold on power.
The city's militarization is one of the elements that could disrupt the whole party vibe for Nicole.
Diseases like congenital cataracts facial dysmorphism neuropathy syndrome are caused by the inclusion of intronic Alu elements that severely disrupt the transcript structure, thereby affecting the function of the resulting protein (Varon et al., 2003).
The genes/proteins organized in these structures are the indivisible elements that are disrupted or regulated abnormally in disease but alterations of different genes/proteins in the same functional unit often converge in a common disease phenotype [ 19].
