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For DBDs, there is a strong clade-specific element in the correlation analysis, which, when analyzed in the light of the many structures of DNA bound DBDs, opens interesting possibilities for the understanding of hormone response elements specificity.
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This autosome-specific binding is conserved in evolution, as demonstrated by the F element specificity (also detected, for instance, in Drosophila pseudoobscura and Drosophila virilis).
The mechanisms that contribute to core promoter element specificity, linked with differential transcription factor usage create a more complex and dynamic layer of regulation mediated by the core promoter itself [26].
XAS displays similar element specificity and local character as XPS (participation of core-hole), but with increased sensitivity to chemical environment through the unoccupied states.
The similarities and differences that exist between EREs and TREs suggest that the underlying mechanisms that confer response element specificity are much more complicated than was once thought.
To ensure that with the hCMV enhancer element specificity is retained, control transfections were carried out in AFP negative cell lines both of human and murine origin.
The advantage of this method over EPR techniques is its element specificity, and they are sensitive only to the protonation states of the ligands of metals.
For the DNA binding domain, particularly, the analysis shows that the main source of correlation comes from residues that regulate hormone response element specificity, and one of the conserved residue sub-sets arises due to the presence of an unusual sequence for the DNA binding motif known as P-box in nematodes, suggesting the existence of different DBD-DNA specificities in nuclear receptors.
The presence of a B3 DNA-binding domain together with a WRKY domain and domains from intracellular resistance proteins suggest that this R protein has at least two different DNA-binding domains with different cis-acting element specificities that could be responsive to both biotic and abiotic stresses.
Collectively, these results highlight the various elements of specificity as they relate to perceptual-cognitive expertise.
Although they do not have formal elements of specificity (prefixes, suffixes, etc)., such units have, from a conceptual point of view, highly precise specialized meanings, as highlighted in the beginning of this text.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com