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In addition, suppressive DNA elements may modulate the stimulatory effects of CpG DNA.
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However, it is known that vCH also receives input from additional contralateral elements which may modulate the directional selectivity.
In the present study, we performed a detailed analysis of the proximal promoter of DHCR24 that allowed the identification of a functional SRE as well as putative cis-acting elements that may modulate the SREBP-mediated regulation.
Although zinc finger genes were not enriched for GOF candiates according to GREAT, two GOFs located upstream of the brain-expressed ZNF131 (Trappe et al. 2002) are notable because they harbor regulatory elements that may modulate its expression (fig. 5).
Suppressive effects of the tumour environment, including locally accumulated suppressive cytokines, and other stromal elements may additionally modulate the efficacy of the fusion protein in vivo.
We have also identified genetic effects on Cu, Se, and Zn, which are not among the toxic elements but are essential and may modulate the toxic effects of the other elements.
The lower stimulation compared with the shorter reporter RNAs suggests that the miR may be somehow sequestered by the very long RNA or that it could be potentially interesting to search for possible regulatory elements in the HCV genome that may modulate the effect of miR-122 on the 5′-UTR.
The up-regulated genes present putative cis-regulatory elements in their promoter region indicating that many transcription factors may modulate the expression of these genes, and that these genes are probably multi-stress responsive.
A related activity of these Paf1C components may modulate heterochromatin spreading by up-regulating histone turnover at boundary elements.
Description of the dose-response relationship involves consideration of the elements or factors related to the pathogen, the host and the matrix, insofar as they may modulate the response to exposure.
Therefore, we hypothesized that PHGDH may modulate autophagy in ECSLCs.
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