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Furthermore, regulatory elements can function at different distances from the splice sites.
Although it is well established that gene regulatory elements can function at long distance (>50kb) and may exist 5', 3' or be intergenic, most plasmid-based reporter systems require that only a relatively small DNA fragment(s) be used.
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At its native location URA3 resides at a distance from its neighboring origins that is ideal to test the outer limits over which the bias element can function.
Sequence elements that can function as internal ribosome entry sites (IRES) have been identified in 5' noncoding regions of certain uncapped viral and capped cellular mRNA molecules.
Minimal promoter elements that can function independently or together, depending on the specific promoter, include the upstream TATA box4,5 and a pyrimidine-rich initiator6 8 (Inr) overlapping the transcription start site.
Our approach therefore is able to efficiently identify genetic elements that can function in influencing genes important for our traits of interest.
The dynamic developmental theory of ADHD suggests that changes in fundamental behavioral selection mechanisms slow the association ("chunking") of simple response units into longer, more elaborate chains of adaptive behavioral elements that can function as higher-order response units [ 17, 92, 93, 102].
In those moments, the high sensation-seeking person is in their element and can function very well where a low sensation-seeking person might crumble.
The region contains a conserved non-coding element that can function as enhancer as well as a repressor and drives Shh expression in the limb.
We show that a conserved neuron-restrictive silencer element (NRSE) can function to restrict transgene expression to the nervous system.
Exploiting our 'Gene_Table' database table, which collects exon/intron structure for each gene product, our aim was to find the minimal intron, namely the minimal known DNA sequence element that can function as an intron.
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