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Computing elements can be located far away from the data storage elements.
The receptor-response elements can be located at large distances from gene targets, indicating that long-range interactions within the nuclear architecture contribute to receptor action.
In humans, enhancer elements can be located over a megabase away from the transcriptional start site [ 8].
The scope of such studies is limited because cis-regulatory elements can be located at considerable distance from transcription start sites, even up to several hundred kilobases away [ 18].
Although some regulatory elements can be located several kilobases away [ 35], studies of the molecular mechanisms of splicing suggest that ESEs occupy specific positions relative to the 5' and 3' ends of exons [ 13, 36].
It is well established that transcriptional regulatory elements can be located within introns, particularly intron 1 [e.g., Surinya et al., 1998; Gemel et al., 1999; Ozaki et al., 2002].
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His last work, the Pathétique, brings full color to many of the story-telling elements that can be located in his ballets and operas as well as his earlier symphonies.
Mammalian genomes are organized into higher-order conformational structures that allow physical interactions of regulatory elements that can be located in far distance on one chromosome or even on different chromosomes (reviewed in Cremer and Cremer 2001).
Expression of a typical animal gene is likely to be governed by several distinct enhancer elements that can be located in 5′ and 3′ genomic regions, as well as within intronic intervals [ 8].
DNA transposons are discrete DNA elements that are able to translocate within the cellular genome by excision and reinsertion mediated by a transposase, which can be encoded by the transposable DNA element or can be located elsewhere in the genome.
Since distal cis-regulatory elements in vertebrates can be located far from the gene [42], we scanned the 150 kb of Olig2 upstream sequence and identified ten regions containing potential regulatory elements which might play a role in controlling Olig2 gene expression.
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