The identified core data elements were organized into a logical model to guide the design of new databases and application programming interfaces.
The information elements were organized into several groups, namely intervention parameters, population description, outcomes, and funding sources.
In addition to the correlation due to overlapping genes, it is well recognized that pathways do not function as discrete elements, but rather are organized into cascades and co-regulatory networks.
Several hypotheses have been raised to account for observed local coexpression, such as that the coexpressed neighbors reside in chromatin domains with open conformation [ 104, 105, 90], have shared regulatory cis-elements [ 106], or are organized into eukaryotic operons [ 107- 109].
Expression of fruitless and doublesex in sensory neurons, interneurons and motorneurons suggests that they are organized into circuit elements capable of receiving, processing and transferring information that controls sexual behavior.
In eukaryotic cells, genomic DNA, including these cis-regulatory elements, is organized with histones and further packaged into a higher order chromatin structure [ 33].
Recent studies revealed that chromosomes are organized into megabase-scale domains that demarcate active and inactive genetic elements, suggesting that compartmentalization is important for genome function.
Most imprinted genes are organized into chromosomal domains, and allelic repression is controlled by essential sequence elements called ICRs (imprinting control regions; Delaval & Feil, 2004).
Proteins are organized into spatially distinct domains that might be established, separated and maintained by boundary elements and/or heterochromatin.
