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We took a conservative approach to determine whether cis-acting elements are conserved among SRRP component upstream regions.
The POTRA5 domain binds BamD between its tetratricopeptide repeats 3 and 4. The interface structural elements are conserved in the Escherichia coli proteins, which allowed structure validation by mutagenesis and disulfide crosslinking in E. coli.
The classes of transposons targeted by germline and somatic piRNA clusters, though not the precise elements, are conserved among Drosophilids, demonstrating that the architecture of piRNA clusters has coevolved with the transposons that they are tasked to control.
Thus, we present evidence that both the sequence and the regulatory characteristics of cis-acting elements are conserved throughout evolution, from teleosts to man.
The A3, E1, and C1 regions are the major glucose-responsive transcription control elements of the insulin gene and these elements are conserved in the Ins2 promoter region [23], [24].
Both of these additional elements are conserved in the promoters of 9 of the ten mtUPR responsive genes we have identified so far, the exception being the Cpn60/10 bidirectional promoter.
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The first is a brightness constancy assumption and it assumes that the intensity of image elements is conserved between the image frames (called the OF constraint).
Furthermore, one of these elements is conserved in sequence and location between the human and mouse Id2 promoter.
The regulatory potential of these elements is conserved and was exploited to direct tissue specific expression of a reporter gene in zebrafish embryos.
None of these transposable elements is conserved in other sequenced Rickettsia genomes.
We found that several cis-acting elements were conserved in promoters of cold- and dehydration-inducible genes using our comprehensive promoter analysis.
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