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In this regard, it has been shown that p73 interacts with p53-responsive elements and induces transcription of p53-inducible genes [ 35].
It has been found that FXR binds to the response elements and induces expression of ADH1A and ADH1B, resulting in increased ADH1 enzymatic activity.
Degradation of IκB allows NF-κB to translocate into the nucleus, where it binds to specific promoter elements and induces gene transcription.
The resulting free NF-κB is then translocated into the nucleus, where it binds to the κB elements and induces the transcription of genes encoding pro-inflammatory mediators and cytokines [ 38, 39].
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Given the complexity of many complexes involving intrinsically disordered regions, interactions involving both conformational selection of preformed elements and induced folding likely occur.
Upon phosphorylation, STATs dimerise via reciprocal SH2-domain/phosphotyrosine interactions, localise to the nucleus, bind to STAT-specific DNA response elements, and induce transcription of their target genes.
In grafting experiments, they demonstrated that the gai transcript specifically entered functional sieve elements and induced a highly reproducible change of leaf phenotype in tomato when Atgai mRNA was transported into the tomato shoot apex [ 14].
While all three C/EBPs can bind directly to these elements and induce PPARγ2 expression, C/EBPα binding replaces early C/EBPs at later stages, which is consistent with their expression patterns [ 48, 49].
Nuclear Nrf2 activates ARE-elements and induces expression of stress-responsive genes [ 10].
This transcription factor binds as a homodimer to the cAMP-responsive element and induces transcription of genes in response to hormonal stimulation [ 25].
The phosphorylated STAT1 and STAT2 dimerize and translocate to the nucleus where they associate with IRF9 to form IFN-stimulated gene factor 3 (ISGF3), bind to IFN-stimulated response elements (ISREs) and induces the expression of antiviral ISGs.
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