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Ms. Pearl's fame has its roots in the most elementary function of the librarian: pressing a book into a patron's hands and saying, "Read this".
Both superfamilies share the elementary function of the copper binding.
The elementary function of the Glycine-rich pre-domain prototype is related to redox reactions revealing evolutionary connection between β/α barrels with different enzymatic functions.
Recently we showed that the profile 14 is a derivative of the ancient prototype with the generic signature -CxxC- and the general elementary function of the metal and metal-containing cofactor binding [ 11].
For instance, the profile 14 with the signature − GMxCx(2 Cx(3)Vx(8)GV- characterizes elementary function of the copper binding (example of EFL structure is shown in Figure 5).
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The elementary function of this EFL is the adenine moiety recognition and binding via a hydrogen bond [ 38].
Although the matches are found in proteins with different biochemical function, they all possess nucleotide-binding activity, which is presumably an elementary function of this prototype.
Ancient elementary functions of the core are also frequently found in the arCOGs present in the "almost-core" arCOGs (between 25 and 38 species) shown by the large blue nodes in Figures 4 and 5.
EFLs representing this prototype universally provide the elementary function of nucleotide triphosphate binding via interaction with the phosphate groups and with a Mg2+ ion, and also take part in phosphate hydrolysis.
CDD and Swissprot features can be used as more precise indicators of the elementary function of EFLs.
Cluster 8 in the Figure 4 shows several profiles with the elementary function of a metal binding.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com