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In two of these lines GFP was expressed in the ChP indicating that the genomic region where they reside is controlled by the same regulatory element that regulates gene expression in the ChP of both diencephalon and hindbrain (Fig. S1C-F).
The ABRE functions as a cis-acting element that regulates ABA-responsive gene expression.
The dehydration-responsive element (DRE), containing the core sequence A/GCCGAC, is a cis-acting element that regulates cold- and dehydration-responsive gene expression in Arabidopsis (Arabidopsis thaliana).
MAFA is a transcription factor binding to RIPE3b, a conserved enhancer element that regulates pancreatic beta cell-specific expression of the insulin gene (INS) [ 62].
Based on our analysis of the chromatin profile at the region around rs6059655, it seems unlikely that this SNP acts as an enhancer element that regulates transcription of GSS (or another pigmentation gene).
The abscisic acid (ABA) -responsive element (ABRE), containing the core sequence ACGTGG/T, is a cis-acting element that regulates dehydration- and high salinity-responsive gene expression in Arabidopsis and rice (Oryza sativa).
Similar(53)
For example, DRE/CRT is the dominant class of cis-elements that regulates a late embryogenesis abundant protein (OsLEA) network involved in dehydration, low temperature and salinity stress mechanisms in japonica rice (Meier et al., 2008).
The transcription repressor Slug is a member of the Snail family of DNA-binding elements that regulates E-cadherin expression [22] and has been shown to be critical for conferring a metastatic phenotype in an experimental model of melanoma [23].
Together, evidence here supports that CR4.2 is a key cis-element that regulates Foxn4 expression in the genesis of the horizontal and amacrine cells.
ECM22, which encodes a sterol element-binding transcription factor that regulates sterol uptake and sterol biosynthesis (Woods and Höfken 2016), is also more abundant.
One potential class of dynamic regulator is the riboswitch: cis-acting RNA elements that regulate the expression of downstream genes based on the presence of an effector molecule.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com