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We postulate that the SNPs we identified may be in linkage with a regulatory element that modulates TERT expression.
Despite this limitation, we believe these preliminary results are compelling since all three polymorphisms occur on the same linkage group (LG 5) believed to contain a cis-regulatory element that modulates cichlid opsin expression, and all three are associated with opsins whose expression is significantly associated with this QTL in African cichlids [ 29].
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In addition, a new regulatory cis-element that modulates the balance between two DNA-protein complexes in vitro was found to be important for EgCAD2 expression in the cambial zone.
The CREB is an activity regulated transcription factor that modulates the transcription of genes with CRE (cAMP responsive element) located in their promoter regions.
Several cognitive symptoms commonly associated with severe AUD, ranging from poor risk management to the cognitive/affective dimension of pain, are probably mediated by altered function of key anatomical elements that modulate PFC executive function, including contributions from the cingulate cortex and insula.
First, it has been proposed that TAS could act as stress response elements that modulate growth by reducing macromolecular synthesis.
These data suggested that one or both of these putative EREs might represent ERα-responsive cis-regulatory elements that modulate PCNA gene expression in MCF7 cells.
It is therefore possible that all three alleles acts as, or are linked to, cis-regulatory elements that modulate opsin expression in cichlids.
The neuronal basis of female sexual behaviors has only recently come into play with studies primarily focusing on sensory elements that modulate postmating responses [ 21,49,50].
These include the range of action of enhancers, the boundaries of expression domains, the presence of silencers or other repressive or insulating elements that modulate enhancer activity and cannot be obtained from other types of datasets and approaches.
Once integrated into the cellular DNA, the transgene cassette is affected by neighboring chromosomal elements that modulate the promoter to a high extent (see West and Fraser, [ 2] for a recent review).
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