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Reporter 3xGRAS-luc (GRAS: GnRH Receptor Activating Sequence) is a synthetic reporter, containing three repeats of a composite regulating element (overlapping AP1, Smad3 and Foxl2 binding sites) which is found in the murine promoter of the GnRH Receptor (GnRHR) and seems to contribute to the regulation of its expression in pituitary gonadotrope cells [29].
In the proximal promoter region of DHCR24 we found one YY1 element overlapping an inverted CCAAT-box similarly to what was found in the HMGCS promoter.
Crosstalk between GR and these transcription factors may occur either through composite response element, overlapping response element, or interaction between GR and transcription factors.
The core promoter consists of two key genetic elements: the TATA box (present in most promoters) and/or an initiator (Inr) element overlapping the transcription start site.
The presence in the HMGCS promoter of one YY1 element overlapping an inverted CCAAT-box (ATTGG) may explain the negative effect of YY1 by competing with NF-Y for the same binding site [ 4].
A rezoning step may be necessary in order to overcome element overlapping or crossing-over.
Similar(54)
Pattern 1 DMRs exhibited a significant depletion of NCEC element overlaps (P <4 × 10-5, Figure 1).
Cyclosporine effective element overlaps the element and confers cyclosporine sensitivity to the cyclin D1 promoter (Schneider et al. 2002).
We calculated the average rate for each element as the sum of the rates of each 10 kb window overlapping the element, with the rate of each window weighted by the fraction of the element overlapped by the window.
If the position of a predicted variant-altered regulatory element overlaps a conserved region, then the cis-regulatory potential of the variant is considered to have functional support.
Eleven families (Dpul_C33, C7, C8, G1, G12, G28, G31, G32, G5, G56, and G8) consisting of more than one element overlapped with the TARs.
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