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The antioxidant responsive element (ARE) is a cis-acting regulatory element of genes encoding phase II detoxification enzymes and antioxidant proteins, such as NAD(P H: quinone oxidoreductase 1 (NQO-1), HO-1, glutathione S-transferases, and glutamate-cysteine ligase.
ARE is a cis-acting regulatory element of genes encoding phase II detoxification enzymes and antioxidant proteins, such as NAD(P H quinine oxidoreductase 1 (NQO1), glutathione S-transferases (GST) and glutamate-cysteine ligase (GCL) (Lee et al. 2003a).
The spliced HAC1 transcript produces the Hac1p basic leucine zipper transcription factor that binds to the UPR element of genes such as KAR2 but also regulates UAS INO containing promoters by counteracting the function of Opi1p (Cox and Walter 1996).
On the other hand, we have shown that the Ying and Yang (YY) downstream motif is a very important constitutive element of genes with broad expression, whereas it appears to be of little relevance in genes that show tissue-specific expression.
The ARE is a cis-acting regulatory element of genes encoding phase II detoxification enzymes and antioxidant proteins, such as NAD(P H quinone oxidoreductase-1 (NQO-1), glutathione S-transferases (GST), heme oxygenase-1 (HO-1), and aldo-keto reductase family 1 member C1 (AKR1C1).
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Hub genes represent an important element of gene network architecture and their existence is empirically confirmed.
TSP-1 was identified as an element of gene expression signatures predictive of poor outcome in pediatric sepsis and in trauma patients [12, 13].
This genetic control evolved through changes within the CRE element of gene bab [34].
Proteolysis of key regulatory factors is an important control element of gene activity both in eukaryotic and prokaryotic cells.
A small portion of the oligonucleotides target unidentified protein coding sequences, thereby providing an element of gene discovery.
Discussing another element of gene regulation, Professor Iain McInness of Glasgow illustrated how miRNA can regulate key events in immune activation.
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