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Hub genes represent an important element of gene network architecture and their existence is empirically confirmed.
TSP-1 was identified as an element of gene expression signatures predictive of poor outcome in pediatric sepsis and in trauma patients [12, 13].
This genetic control evolved through changes within the CRE element of gene bab [34].
Proteolysis of key regulatory factors is an important control element of gene activity both in eukaryotic and prokaryotic cells.
A small portion of the oligonucleotides target unidentified protein coding sequences, thereby providing an element of gene discovery.
A specific cis-acting element of gene enhancer in CYP3A4 has also identified which confers HNF4α binding and permits PXR- and CAR-mediated gene activation [ 22].
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The antioxidant responsive element (ARE) is a cis-acting regulatory element of genes encoding phase II detoxification enzymes and antioxidant proteins, such as NAD(P H: quinone oxidoreductase 1 (NQO-1), HO-1, glutathione S-transferases, and glutamate-cysteine ligase.
The spliced HAC1 transcript produces the Hac1p basic leucine zipper transcription factor that binds to the UPR element of genes such as KAR2 but also regulates UAS INO containing promoters by counteracting the function of Opi1p (Cox and Walter 1996).
ARE is a cis-acting regulatory element of genes encoding phase II detoxification enzymes and antioxidant proteins, such as NAD(P H quinine oxidoreductase 1 (NQO1), glutathione S-transferases (GST) and glutamate-cysteine ligase (GCL) (Lee et al. 2003a).
Moreover it can in principle incorporate other elements of gene regulation different from TF like post-transcriptional regulation by means of differential mRNA stability [14], [15].
Most recently, a New RNA World has been recognized in current organisms, in which the RNA is an integral component of chromosomes and the different types of RNA are key regulatory elements of gene expression (e.g. [16]).
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