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The ontogeny of function, at all levels of organization, is an element of developmental biology, but it is often bracketed because of the predominance (both past and present) of questions surrounding the ontogeny of form or structure (Love 2008b).
Subunit GluRIIA and B competitively bind to GluRIIC; hence, the preferential expression of these two subunits constitutes one element of developmental plasticity exhibited by this synapse (Marrus et al., 2004).
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Here, we review recent advances that have helped to unravel distinctive elements of developmental programming for Tfh cells and unique effector Tfh cell functions focused on antigen-primed B cells.
In fact, no element of the developmental matrix plays any privileged causal role not genes, not organisms, not the environment, not anything.
- The capacity-building and empowerment strategies are main success elements of any developmental project.
Compelling as they are, the key elements of such developmental accounts have proved difficult to verify empirically.
Some ultraconserved elements in the noncoding regions of mammalian genomes have been shown to function as regulatory elements of neighboring developmental genes [ 3, 4].
While in these comparisons we do not intend to convey a tight homology in gene expression patterns across deuterostome phyla, we predict that similarities in the overall patterning are an ancestral innovation and perhaps evidence of maintenance of some elements of a developmental gene regulatory network (GRN) inherited from a common ancestor.
Epigenetic processes such as alternative histone marking by methylation (dpy-30), alternative splicing and small RNA-mediated regulation of gene expression (ago-2), and perhaps also ER processing and ERAD degradation of newly synthesized proteins, emerge as potentially important elements of the developmental switch.
The costs estimated here represent just one element of the costs of developmental delay associated with ETS.
The shadow enhancers consisting of transcription factor binding site tandems, usually degenerative, were described as important cis-regulatory elements in a number of developmental genes in animals [ 44- 46].
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