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Chromium (Cr), a trace metal element, is implicated in diabetes and cardiovascular disease.
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Although the repetitive element was implicated in the inversion, no clear model explained its role mechanistically.
ABA-responsive element (ABRE, PyACGTGGC), an important cis-element, is implicated in the transcriptional regulation of ABA- and/or stress-responsive genes [ 8].
A similar observation has been made in clinical isolates of Enterococcus faecium in which IS elements were implicated in developing new subspecies that are better adapted to a hospital environment [ 23].
Finally, various types of MITEs (miniature inverted repeats transposable elements), which are predicted to be derived from autonomous transposable elements, are implicated in transcription regulation and other processes [ 6, 7].
Chromatin boundaries or insulator elements are implicated in regulating genome-wide chromatin-mediated effects and are crucial for blocking inappropriate gene expression to provide functional autonomy of chromatin domains [ 10, 11].
It is implicated in the civilian deaths.
FAK is implicated in myofibroblast differentiation.
Bmi1 is implicated in cdki regulation.
Both class I elements (retrotransposons) and class II elements (transposons, including foldback elements) have been implicated in the generation of rearrangements in a wide array of organisms [2], [8], [9].
Interestingly, elements related to each of these have been shown previously to have stabilizing effects for individual genes: a GA-rich element has been implicated in stabilizing the elastin mRNA [27], CA repeats bind to hnRNP L and confer resistance to decay [28] and CU-rich and pyrimidine-rich elements interact with HuR or αCP complexes to stabilize mRNAs [29], [30].
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