An important element postulated in the pathogenesis of the prothrombotic state in diabetic patients is platelet hyper-reactivity.
Inflammation of the airways is one of the key elements of the pathogenesis of the disease: it is responsible for the destruction of lung architecture, resulting in progressive loss of respiratory function.
Some authors have implicated endothelial cell damage as a prime element in the pathogenesis of demyelination.
Chronic inflammation of the arterial wall is a key element in the pathogenesis of atherosclerosis, yet the factors that trigger and sustain the inflammation remain elusive.
These results suggest that intramitochondrial oxidative stress is an important element in the pathogenesis of SA, and is sufficient to induce pathologic iron accumulation in mitochondria of developing RBC [27].
This observation is in line with previous findings showing that such somatic mutations occur often in lymphocytes, a process which is considered to be a major stochastic element in the pathogenesis of autoimmunity [10], [11].
Inflammation is an important element in the pathogenesis of COPD.
Insulin resistance is a key element in the pathogenesis of type 2 diabetes mellitus.
Oral inflammation is an important element in the pathogenesis of vascular disease.
Aberrant post-translational modification (PTM) of proteins is emerging as an important element in the pathogenesis of HD.
Sumoylation of HDAC4 may prove to be an important element in the pathogenesis of RA (Table 1).
