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It has been proposed that the binding of N II) ions within the cell nucleus is a crucial element in the mechanism of carcinogenesis.
The presence of both α-syn and γ-syn in brain deposits in several NDDs may suggest a common element in the mechanism leading to these disorders.
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The finding that antagonism of adenosine-A1 receptors occludes FF and facilitates mossy fiber LTD suggests that this receptor is an intrinsic element in the mechanisms underlying these effects.
Dangerousness, avoidance and character weakness are the main elements in the mechanism underlying stigma against mental illness [ 4].
Thus, this observation demonstrates an important element in underlying the mechanism of PEDF therapy to counteract VEGF-related actions during neoangiogenesis.
Conservation of these contacts in AMPA and kainate receptors indicates that they are important determinants of dimer stability and that the dimer interface is a key structural element in the gating mechanism of these glutamate receptor families.
Given the common presence of a local ischemic element in the prolapsing mechanism, this latter observation is anticipated.
If the ions act indirectly through the bilayer or via an intracellular site, however, the E543 residue must still be a crucial element in the coupling mechanism to channel opening.
The following study identified ENVOY as a central regulatory element in the fine-tuning mechanism of G-protein signaling.
An apodeme in the hind legs of locusts, for example, is one of the important elastic elements in the catapult mechanism that powers jumping.
The new modules also have piezoelectric elements in the actuator mechanism to make the lenses focus (instead of voice coil motors).
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