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Although iron is an essential trace element important for many biological functions it could be harmful because iron excess can induce the production of reactive oxygen species, development of oxidative stress and lipid peroxidation which leads to demyelination.
We used the resulting multi-species alignment to analyze whether any of the detected variation marks out any sequence element important for regulation by modulators or regulating factors.
Furthermore, exon 3 in particular contains an element important for binding to CTIF, SLIP1, eIF3 and PAIP1 [ 22, 25, 46].
Manganese (Mn) is an essential trace element important for neuronal function; however, excessive exposure to Mn has been associated with a severe movement disorder known as manganism.
It is also a possibility that these motifs are not transcription factor binding sites; they might represent some other cis element important for other mechanisms of gene regulation, such as binding sites for proteins involved in epigenetic regulation.
Intron 1 was crucial as it contained an enhancer element important for strong chondrocyte-specific expression, which was also investigated in mouse and chick embryo chondrocytes derived from sterna of 15-day-old embryos [ 2, 13].
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Two non-consecutive hydrophobic structures termed "spines" anchor all the elements important for catalysis to the F-helix.
Among the elements important for steroid production is steroidogenic acute regulatory protein (StAR) which acutely delivers cholesterol from the outer to the inner mitochondrial membrane for rapid steroidogenesis.
When P-site inhibitors were soaked into native crystals of the complex, the active site of adenylyl cyclase was located and structural elements important for substrate recognition and catalysis were identified.
Instead, the region between −165 and −35 contains elements important for NFATc1 induction of TRAIL expression.
These results suggested that probes 4 and 5 contain elements important for NFATc1 induction of TRAIL expression.
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