Sentence examples for element binding to from inspiring English sources

The chimera consisted of EGF as a cell targeting element and interferon-α-2a (IFNα-2a) as the activity element binding to the IFN-2a-IFNα receptor 2 (IFNR).

The ORF of rpsB genes have recently been shown to be preceded by a conserved specific motif in the 5'UTR, which could be a cis-regulatory element binding to the S2 protein for an autoregulatory control of its own synthesis [ 52].

Response elements binding to CAR are usually composed of two direct repeats of the consensus hexametric sequence of AG(G/T TCA spaced by three to four nucleotides (i.e., DR3 or DR4) (Makinen et al., 2002).

In accordance with the methods we chose for computerising and applying guidelines, our technical environment consisted of GDL rules to represent guideline knowledge, openEHR archetypes to handle clinical knowledge elements, the openEHR RM to handle archetyped clinical data elements, bindings to the terminologies SNOMED CT, ICD-10 and ATC and the dADL format for storing patient data.

This in turn leads to an adenylyl cyclase-mediated cAMP increase, activation of protein kinase A (PKA) [ 37], and finally to binding of the transcription factor CREB (cAMP-responsive element binding protein) to specific cAMP-responsive elements on the DNA [ 38].

The bound androgen receptor acts as transcription regulatory element by binding to specific DNA response elements in target gene promoters, causing activation or repression of transcription and subsequently protein synthesis.

As the RXRα homodimer binds to both response elements, hRXRα binding to each response element was used as a positive control.

Whereas the LEDGF/p75 C-terminal part (IBD) interacts with HIV-1 IN, the N-terminal part of LEDGF/p75, consisting of a PWWP (Pro-Trp-Trp-Pro) domain, a nuclear localization signal (NLS), two AT-hooks and a supercoiled DNA recognition element ensures binding to chromatin and DNA35,36,65.

Molecular docking displayed that α-methylene-γ-lactones moiety represents a key element for binding to the ATP pocket of both PI3Kα and mTOR, via hydrophobic interaction and hydrogen bonds.

However, we cannot exclude that other cellular mechanisms are involved, such as activation of the transcription factor cAMP-responsive element binding protein via binding to nonclassical membrane ERs (Quesada et al. 2002).

Catalytically active PKAc also translocates to the nucleus where it phosphoylates the transcription factor cAMP response element binding protein (CREB) to regulate gene expression [10].