Elegant "metal specificity switch and rescue" experiments that are well established for ribozymes showed that metal ion coordination disrupted as a result of oxygen-sulfur substitutions can sometimes be restored if a softer metal cation such as Mn2+ is supplied to the reaction [ 21, 22].
PUMILIO is a prototypical PUF protein whose RNA sequence specificity is simple, elegant, and predictable.
Walker et al. [33], [34] describe an elegant series of assays demonstrating the specificity of the dog, pig, guinea pig, cow, chicken, cat and mouse primers for both single species and mixed species DNA samples.
In this organism, an elegant 'self-reinforcing loop' model explains the specificity of heterochromatin formation based on the role of the RNAi machinery (reviewed in [7] [9]).
Due to the modularity of TALEs and the restriction of base specificity to the RVDs, an elegant code governing the DNA recognition specificity was elucidated [ 59, 72].
Although less well known than its successor, The Garden of the Finzi-Continis, it offers perhaps the most concise distillation of Bassani's art: elegant, elegiac, and with a profound attachment to the specificities of time and place.
30, 50– 52 An elegant study by Pallier et al. 53 explored the specificity of IFG involvement in hierarchical syntax by crossing two manipulations.
The elegant subtlety of these responses and the co-evolved species specificity predestinate this natural ecological U. minor - X. luteola - O. gallerucae system for studying egg-induced transcriptional changes in plants.
Overlapping specificity for some yeast PATs was also shown using an elegant proteomics approach [15].
In elegant molecular engineering work, the Fierke laboratory was able to tune the specificity and affinity of CA to create a series of probes that could respond to physiological concentrations of Zn2+.
