A focused dataset of previously synthesized and tested [1,2,4]-triazolo[1,5-a]pyridines and pyridine-3-carboxylates wastudieded by Molecular Field Topology Analysis (MFTA) to identify steric and electronic determinants of anti-inflammatory activity useful for the design and synthesis of new anti-inflammatory agents.
In this perspective, we have shown that environmental and endogenous aldehydes can be described by their relative softness and electrophilicity, which are important electronic determinants of the respective second-order reaction rates with nucleophilic targets on macromolecules.
Two cross-sectional surveys revealed technical support as determinant of electronic health records acceptance [ 45, 74].
Ten cross-sectional surveys disclosed workflow as determinant for electronic health records acceptance [ 3, 43- 47, 48, 48, 68, 69, 73, 74].
Taken together, our results indicate that CK2 is a potentially important regulator of KCNJ2 gene expression and an important determinant of cardiac electronic instability following MI, via IK1.
User attitude towards electronic health records is a strong determinant for their adoption.
Eleven studies established expert support as a very determinant factor for adopting electronic health records [ 4, 5, 7, 15, 24, 25, 28, 31, 45, 66, 76].
The interface design and its effect on workflow are key determinants of the usability of electronic medical records (EMRs) in the emergency department (ED).
Hydrophobic substituents on the carboxamide group increased cytotoxicity but substitution by a hydroxy group diminished it, thus pointing to the electronic density on benzo[b]thiophene nucleus as a determinant factor.
The most important determinants for the activity in these models are Hammett electronic (σ and σ+), hydrophobic, molar refractivity, and Sterimol width parameters.
Data on possible determinants were obtained from the first questionnaire and the electronic client records.
