Static RAM (SRAM) consists of flip-flops, a bistable circuit composed of four to six transistors.
For example, in [17], a negative feedback loop using a switched capacitor network is used to adjust the DC bias of their proposed bistable circuit.
This network structure is functionally similar to a bistable circuit with mir173 as a switch.
Once a cell passes the branching point, the two genes are regulated in opposite directions according to the bistable circuit.
A more confident prediction would likely require greater structural and kinetic details of pertinent signaling pathways leading from exposure to LPS and TCDD up to the bistable circuit, and perhaps a more complete description of the bistable circuit itself.
Importantly, a bistable circuit would also make the differentiation physiologically irreversible, a property that is likely to contribute to the maintenance of the acquired immunity after antigen encounter.
In this case it may be that some upstream signalling actually provides the spatial switching, which is partly accentuated by the bistable circuit.
Here we review the basic properties of bistable circuits, the requirements for construction of a satisfactory bistable switch, and the recent progress towards constructing and analysing bistable signaling systems.
Kal'yanov, E.V. "Chaotic oscillations and their interaction in a symmetric system of two bistable circuits coupled via a low-pass filter," Radiotekhnika i Elektronika, vol.46, no.6, pp.710-723.
Building these monomeric transcription factors in a properly designed network [33], the experimental implementation of monomeric bistable circuits seems thus to be feasible.
Firstly bistable circuits may be able to act as spatial switches if all elements are weakly diffusible (or non-diffusible).
