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In this work we demonstrate how water-enhanced electrical coupling to guarding electrodes is a key mechanism in achieving response immunity to parasitic electric-field bending without impairing the detection performance of the polymer-coated IDE platform.
During the peak of the depolarizing response, spikelets, indicative of electrical coupling to other neurons, were sometimes seen.
The lessons learned then from subdural placement of the electrodes (excellent electrical coupling to the spinal cord, improved site-specific stimulations), in conjunction with the availability of modern neurosurgical materials and technology, suggest that this approach should be reinvestigated.
In spite of these difficulties, it was recognized that subdural placement of the electrodes improved electrical coupling to the spinal cord [ 28] and was particularly important when the specific site of stimulation on the dorsal columns was critical [ 29].
The model of Nam and Fettiplace [ 183, 193] has used a mechanical model along with electrical coupling to investigate the effects of the hair bundle motility and the cochlear amplifier in high and low auditory frequencies.
Note that for the sake of simplicity, electrical coupling to the SMC layer through myoendothelial junctions, necessary to cause SMC hyperpolarization and hence vasodilatation, was not included in the theoretical analysis.
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Dye-coupling experiments were also performed, although it may be more difficult to estimate the extent of electrical coupling due to various dye permeability and diffusion properties.
Both ERP prolongation (likely mediated by improved intercellular electrical coupling leading to increased liminal length for impulse formation) and positive ventricular structural remodeling contribute to the reduced ventricular arrhythmogenesis.
An improvement of the electrical coupling up to 20 dB is observed for small electrodes, in simulation.
In addition, the electrical coupling due to the electrical impedance of solution is diminished by extending the flow path between them with an extended-design flow channel.
Further increase of the electrical coupling leads to the appearance of the IP pattern (see vertical line area, Fig. 2C1), which coexists with AP in some parameter domain (underlined surface Fig. 2C1).
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