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Chemical, structural and electrical alterations in PMMA thin film after irradiation with different doses were monitored using Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and frequency dependent dielectric measurements, respectively.
We should also consider that animals that not evolve to SE after pilocarpine injection may have a "natural" lower sensitive for seizures (higher threshold), justifying the long-term epileptogenic required time and their lower frequency of SRS (when compared to PILOSE); it becomes thus important to identify the individual susceptibility to electrical alterations in new experiments.
This indicated electrical alterations in the heart of FFFRs.
Not only does the heart remodel structurally with prolonged intensive exercise, but athletes also demonstrate a spectrum of electrical alterations in the 12-lead ECG.
Mutations in ion channels involved in this system can cause electrical alterations that, in certain circumstances, such as during exercise or emotional stress, could trigger arrhythmias.
Mechanistically, it has been suggested that at least part of the electrical alterations observed in knockout mice was due to the increased expression of Irx5 and Irx4, two transcription factors that regulate endogenous levels of Kcnd2, a K+ channel protein involved in cardiac repolarization [ 37].
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The pathophysiology of CIP/CIM is very complex and many factors and mechanisms, such as electrical, microvascular, metabolic alterations, bioenergetic failure and altered Ca2+ homeostasis, have been suggested to explain the observed changes in the neural and muscular system [ 11].
The pathogenesis of CIP and CIM is elusive, possibly involving microcirculatory changes, metabolic alterations, electrical abnormalities, and bioenergetic failure [ 19].
We show that only spinal motoneurons that display the immediate firing pattern undergo substantial electrical and morphological alterations in neonatal mSOD1 mice whereas no changes occur in the motoneurons displaying the delayed firing pattern.
Although the effects of acute ischaemia on human cardiac gap junctions are difficult to investigate directly, studies on experimental animals demonstrate rapid dephosphorylation of Cx43, electrical uncoupling and alteration in the distribution of gap junction immunolabel to the sides of the myocyte (referred to as 'lateralization').
All of these findings support the hypothesis that RSV can specifically alter the electrical conduction system, but that these alterations are benign and transient.
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