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Analogous to the beneficial effects of physical exercise on vascular reactivity (Lenasi and Strucl 2004), naturally occurring exposure to cold of the hands might keep the skin of elderly "fit" to respond to daily changes in environmental temperatures.
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"It definitely is this uniquely interactive form of data". Liutkus-Pierce recalled helping one elderly woman fit her foot into one of the impressions.
Interestingly, in a phase II erlotinib trial that did include elderly patients (fit for chemotherapy), the reported ICER was €395 400 (£341 198/QALY).
Some retrospective data have also concluded that CCRT is feasible and improves OS and RFS in elderly but fit patients with acceptable toxicity [ 21– 23].
Whether to choose hemiarthroplasty or total hip arthroplasty in the treatment of displaced femoral neck fractures in the most elderly and fit patients are often debated.
In order to include the maximum number of elderly individuals fitting these criteria the study period was extended to sixteen months to include the last two months of 2009 and the first two months of 2011.
As in the predecessor phase II trial in elderly, non-fit AML patients receiving DAC (study 00331, NCT00866073), systematic functional assessment of the patients is being conducted prior to randomization and at several defined time points during and after the study treatment [ 27].
Other scoring systems exist, but the ultimate aim is to ascertain if the patient is to be regarded as "fit elderly" or "frail elderly" to guide more aggressive radical treatment.
138 In fit elderly women aged 70 85 years with HR-negative early BC and a significant risk of recurrence, four cycles of non-pegylated liposomal doxorubicin plus cyclophosphamide was feasible but had a certain impact on social and role functioning; however, autonomy was preserved and toxicity was acceptable.
Chemotherapy and trastuzumab seem to be interesting in fit elderly patients with HR-negative and HER2-positive BC. 43 For frail or elderly patients, sequential chemotherapy might also be appropriate in order to avoid the toxicity of combination chemotherapy.
Although many studies have demonstrated that medically fit elderly patients have the potential to derive similar benefit from chemotherapy as younger patients, treatment of elderly patients with colorectal cancer remains conservative outside of clinical trials.
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