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Due to the potential toxicity and adverse effects of TCAs, especially in the elderly population, consideration of dosing levels is important.
We believe that performing a rhinoplasty in the elderly demands consideration of the psychological implications and from a technical standpoint greater care in performing all resections in view of the thinning of tissues and of the underlying anatomical structures.
Conventional pain therapies, while verified in younger adults cannot be automatically applied to the elderly without consideration of all these factors and in no other group of patients is a holistic approach to treatment more important.
Thank you for sending your work entitled "Autophagy as a critical regulator of CD8+ T cell memory and a route to improved vaccination in the elderly" for consideration at eLife.
As most patients are elderly, dose considerations are not a major drawback and its ability to image well the ribs, sternum, scapulae and sacrum in addition to the fact that intravenous contrast is not necessary makes it a realistic alternative in the clinical scenarios outlined above.
The DPP-4 inhibitors have generated particular interest for the treatment of older patients with T2DM for a number of reasons, namely their convenient oral dosing, the importance of avoiding hypoglycemia in the elderly, and considerations of declining renal function in this patient group.
Do we want them to prioritize saving children, or do the elderly deserve equal consideration?
Administration of medication to elderly patients necessitates consideration of the physiological changes which accompany aging.
The elderly require special consideration in many areas because of their frequent comorbidities, frailty, social isolation, and financial limitations.
In addition the elderly need special consideration for adherence to medication regimen and drug delivery (Priano et al 2006).
13 Finally, the recognition of muscle strength and performance as a defining component of sarcopenia in the elderly patients needs consideration, within the context of cancer cachexia.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com