It also seems possible that more complex patterns of exocytosis would have required a concomitant elaboration of pathways of endocytic recycling, which may account for the expansion of the Rab1 family to generate more Rabs associated with Golgi functions, such as Rab19/43, Rab30 and Rab33.
We also highlight cases in which duplicated genes regulate distinct paralogous targets revealing pathway elaboration after whole genome duplication.
The absence of some components in some non-bilaterian species may represent a progressive elaboration of the pathway during early metazoan evolution, or else may correspond to secondary losses in some lineages.
Natural product synthesis continues to provide an attractive platform for the discovery of new synthetic methods and further elaboration of novel synthesis pathways.
The manuscript has a large number of such ambiguous terms: e.g., "structural opportunities", "elongation of pathways", "metabolic elaboration", "biochemical scope", "biochemical space", etc.
Providing a paper-patient case as a context to learn basic science knowledge (as is for example done in problem-based learning [ 10, 11]), appeals to the mechanisms through which the cognitive dimension of context should improve learning and retrieval: activation of prior knowledge, storage of retrieval cues and elaboration (storage of retrieval pathways).
These will also allow refinement of experimental approaches to explore physiological pathways (such as elaboration of the importance of the sex steroid environment) as well as novel treatment strategies across a wide range of conditions requiring manipulation of gonadal function.
Comparison of these empirical data with the "maximum possible elaboration" – the longest metabolic pathway structurally possible in the connected avian carotenoid network (Fig. 3b, Additional file 5: Figure S3) – suggests that dietary robustness enables metabolic pathway elongation by extending time available for its evolution.
The involvement of several pathways deserves further elaboration.
And as there's a progression, elaboration of features along the pathway.
