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Equally, relevant methods should be developed for the statistical elaboration of the data derived from organic materials.
All the elaboration of the data results in one safety index for the current driver and situation.
Target proteins were chosen upon evaluation of the proteomics analysis (differential quantitation) and in silico elaboration of the data, through the consideration of a series of criteria including high degree of nodes, centrality in the groups emerging from the protein-protein interaction analysis and most relevant biological/molecular functions.
MK and NR participated in the elaboration of the data.
In the process of extracting concepts and categories from the data utilising a coding scheme, discussions were continued until an agreeable conclusion was reached among the researchers regarding the further elaboration of the data analysis.
As soon as we perceived the carcinogenic effects of APM during the elaboration of the data in our first mega-experiment (Belpoggi et al. 2006; Soffritti et al. 2005, 2006), we planned an integrated program of long-term bioassays, beginning treatment from prenatal life, on > 4,000 rats and mice in order to better quantify the carcinogenic risks of aspartame.
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Elaboration of these data results in the calculation of a similarity matrix, where the degree of judgments' similarity of each pair of stakeholders' groups (i, j) is presented.
2We adopt the RAND HRS elaboration of this data.
The greater accuracy of data collected from HPF-fixed specimens became fully apparent after the HCA and further elaboration of these data with a 3D agent-based mathematical model of the beta cell and its organelle content.
This article can be regarded as a further elaboration of the Bulgarian data and an extension to the three other countries for which we also have data.
The pre-publication history for this paper can be accessed here: http://www.biomedcentral.com/1755-8794/4/71/prepub wouldulikeike to thank Susanne Bauerschmidt and Jan Polman (Merck, Oss, The Netherlands) for the performance and elaboration of the Affymetrix data, Prof. Rainer Breitling for critical discussions and Heleen de Weerd for bioinformatical assistance.
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