The absence of some components in some non-bilaterian species may represent a progressive elaboration of the pathway during early metazoan evolution, or else may correspond to secondary losses in some lineages.
Natural product synthesis continues to provide an attractive platform for the discovery of new synthetic methods and further elaboration of novel synthesis pathways.
The manuscript has a large number of such ambiguous terms: e.g., "structural opportunities", "elongation of pathways", "metabolic elaboration", "biochemical scope", "biochemical space", etc.
A central tenet in biochemistry for over 50 years has held that microorganisms, plants and, more recently, certain apicomplexan parasites synthesize essential aromatic compounds via elaboration of a complete shikimic acid pathway, whereas metazoans lacking this pathway require a dietary source of these compounds.
These will also allow refinement of experimental approaches to explore physiological pathways (such as elaboration of the importance of the sex steroid environment) as well as novel treatment strategies across a wide range of conditions requiring manipulation of gonadal function.
The biosynthesis of the lignin polymers derives from the general phenylpropanoid pathway which provides precursors for several branch pathways leading to the elaboration of a wide range of compounds involved in various aspects of plant development and defence [ 2].
Recently, Padey et al. (2013) presented a new methodology to address these issues for the wind electricity pathway, with the elaboration of a framework to develop simplified models able to estimate GHG emissions for a large sample of case studies not restricted to those already available in literature.
All the results were entered into a Microsoft Access database (Redmond, Washington, USA) for analysis and elaboration of the screening and management diagnostic pathway.
Increasing evidence proposes a major role for the Wnt pathway in the elaboration of bone disease, as well as its physiological role in skeletal development and cellular differentiation.
Providing a paper-patient case as a context to learn basic science knowledge (as is for example done in problem-based learning [ 10, 11]), appeals to the mechanisms through which the cognitive dimension of context should improve learning and retrieval: activation of prior knowledge, storage of retrieval cues and elaboration (storage of retrieval pathways).
