On the right side, Tcf7l2 cell/lineage autonomously promotes the elaboration of dHbm character typical of most right-sided neurons.
The left-sided parapineal promotes the elaboration of dHbl character in the left habenula, albeit by an unknown mechanism.
They also indicate that the abrogation of functional Tcf7l2 has similar phenotypic consequences on both the left and right sides (parapineal independent elaboration of dHbl character), although the phenotype is only obvious on the right.
The elaboration of leading characters, political factions and major historical events is sometimes a very dry exercise in world building, but done with enough skill it can spark a deeply satisfying response.
In contrast, embryos in which the parapineal was ablated subsequent to its role in elaboration of dHbl neuronal character still showed light responses in the left dHb.
In this study, we identify Tcf7l2 as a critical regulator of brain asymmetry that mediates the elaboration of distinct differentiated character for equivalent neurons on the left and right sides of the brain.
The parapineal is required for elaboration of left-sided character of dHb neurons, and parapineal-ablated fish show largely double-right-sided habenulae [ 5, 6, 11], in which both left and right nuclei are innervated by mitral cells [ 21].
A deep elaboration of the status, role and character of the interpersonal ethos and how it can be promoted is likely to be more easily picked up by interculturalists, as they reflect on the preconditions of mutual respect behind daily interactions in such a way that contact and cohesion is more likely to be effective.
The simplest explanation is that Tcf7l2 normally functions within most right-sided dHb neurons to prevent elaboration of typically left-sided character.
This particular feature has been suggested to render these groups of organisms especially conducive to sexual selection and, therefore, to have favoured the elaboration of male secondary sexual characters [ 42].
What makes his imaginative elaboration of a real historical case especially compelling is his portrayal of Greta, who is a wonderfully successful character, more so in many ways than Einar.
