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The collection of protein and peptide information, along with the proteins' cellular locations and molecular functions, together with expression patterns in differentiated tissues and cells provides a powerful means for elaborating hypotheses about potential biomarkers in serum/plasma, before validating them by targeted assays.
On the question, "was Jesus married?," all the evidence still points toward an absolute negative – and yet this obvious answer is ruled out a priori, in favor of more elaborate hypotheses about how a later "ideal of celibacy" drove the Christian churches to purge every reference the Jesus- Magdalene relationships from their texts and gospels and traditions.
New or more elaborate hypotheses can be added in the future and hypotheses with little empirical support can gradually be dropped from consideration.
The geologists, Dr. William B. F. Ryan and Dr. Walter C. Pitman 3rd of Columbia's Lamont-Doherty Earth Observatory, elaborated their hypothesis in a book, "Noah's Flood: The New Scientific Discoveries about the Event That Changed History," published in 1999 by Simon & Schuster Inc.
We have elaborated this hypothesis on localization signals: ligands to G protein-coupled receptors (GPCRs), which are chemokines and neurotransmitters as well, might chemotactically guide tumor cells to their destination of metastasis formation [ 4].
Anand et al. elaborated a hypothesis explaining why they had found only the G4-G5-G1-G2-G3 permutation of the GTPase domain (see also the expanded discussion on their claims incorporated into the revised manuscript upon suggestion of the second reviewer).
We further elaborated this hypothesis by comparing the lowest free energy structures of the donor- and acceptor sites of all exons that were prone to skipping (bold in Table 1) to their first higher free-energy structures using the mfold program [ 26, 27].
These results lead me to elaborate various hypotheses on several aspects of MHC evolution.
Today, even more sophisticated methods make it possible to identify subgroups of QoL change patterns from scale scores (quantitative variables) and to elaborate specific hypotheses in each subgroup of patients [ 21– 23], thus making it possible to model individual-level characteristics in these patterns.
If you want to indulge in a more elaborate hypothesis, I might offer this one.
To test this elaborate hypothesis, Braun and his colleagues constructed a simulated piece of porous rock from a network of tiny glass capillary tubes heated on one side.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com