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We think this down regulation of Wnt/β-catenin signaling is interesting; however, it would require more elaborate experiments that are beyond the focus of this study.
Wang and colleagues recently carried out elaborate experiments that enabled them to identify BAF155 (a subunit of the SWI/SNF complex) as a substrate for CARM1 methyltransferase and to provide insight into the mechanism by which this factor can lead to or enhance the process of cancer origin development and progression [ 7].
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Models derived for P450s have evolved from simple comparisons of known substrates to more-elaborate experiments that require considerable computer power involving 3D overlaps and docking experiments.
Brain scans enthrall us, in part, because they seem more like "real" science than those elaborate deductive experiments that so many psychologists perform.
What you're basically doing is elaborate thought experiments that are somewhat disciplined by the data, and which you hope are more informative than just plain guesses.
Emerson, following a series of elaborate experiments, concluded that excessive IAP diminished venous return to the heart, resulting in cardiovascular failure [ 1].
Recent publications have demonstrated a shift in focus from generating exhaustive tissue and blood miRNA screens (see online supplementary table S1) to carefully designed functional experiments that elaborate actions of individual miRNAs in known pathogenetic pathways in IBD as implicated by GWAS.
More elaborate experiments have suggested that, far from simply re-running a mental videotape of past events - memory, says Dr Oakley, doesn't work like that - the subject is confabulating them from a mixture of family memories, photographs and their own ideas about the past.
Teschke's group has also carried out elaborate experiments which establish that these ts mutants are indeed destabilized (S.M. Doyle et al. JBC 2004).
The experiments that establish this point are described with such an elaborate layering of deletions that the Reviewing editor found the logic very hard to follow.
A search on Google revealed several Web sites that elaborated on the theories and suggested that Camp Hero was the site of time-travel experiments that picked up where the Philadelphia Experiment — in which a 1940s Navy ship and crew were said to have been made invisible and teleported from Philadelphia to Norfolk, Va.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com