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As soon as parental consent has been obtained for an eligible infant, the recruiting TOBY clinician will telephone the randomisation service and obtain treatment assignment, which will be either to "intensive care with cooling" or "intensive care".
In the Action to Control Cardiovascular Risk in Diabetes-Memory in Diabetes (ACCORD-MIND) randomized controlled trial (RCT), almost 3,000 older people with type 2 diabetes were assigned either to intensive treatment of hyperglycemia or to standard therapy [ 17].
Patients were randomly assigned either to intensive insulin therapy (insulin infusions to keep blood glucose between 4.4 and 6.1 mmol/l [80 110 mg/dl]) or to standard therapy (insulin to be administered if blood glucose exceeded 12 mmol/l [215 mg/dl] and eased when levels fell below 10 mmol/l [180 mg/dl]).
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All 10,251 participants were randomized either to comprehensive intensive glycemic therapy targeting A1C <6.0% or to standard glycemic therapy targeting A1C 7.0 7.9%.
This group appears to respond poorly to either intensive treatment or R-CHOP-like regimes [ 27– 29], and the underlying mechanism remains largely unknown and the appropriate treatment still needs to be established.
In Arabi's mixed medical and surgical ICU single-centred study, 623 patients were randomly allocated to either intensive insulin therapy (aiming to keep glucose levels between 4.0 and 6.1 mmol/L) or conventional insulin therapy (between 10.0 and 11.1 mmol/L).
This finding has also been confirmed within a randomised-controlled trial [ 12] in which children with chronic pain were assigned to either intensive interdisciplinary pain treatment or to a waiting-list control group.
In this randomized controlled trial, patients with the combination of type 2 diabetes and microalbuminuria, many also being hypertensive, were randomized to either intensive risk factor control or to standard therapy.
In contrast, crop colonization by mirids was reduced by nearby orchard, which reflected either sink effects due to intensive management practices or dilution effects linked to herbaceous resources.
In this study, the investigators randomly assigned mechanically ventilated SICU patients to either intensive insulin therapy (IIT; blood glucose target 4.4 to 6.1 mmol/l) or conventional treatment (blood glucose target 10.0 to 11.1 mmol/l).
Before the UKPDS, the concept of glycemic legacy had been reported in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Intervention and Complications (DCCT/EDIC) trial, a study similar to UKPDS, but performed in 1,441 patients with type 1 diabetes randomized to either intensive or conventional glycemic control (22).
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