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The mechanisms regulating taurine levels in retinoblastoma are unclear but may involve either regulation of its synthesis from the precursor hypotaurine and/or regulation of uptake from the extracellular environment, mediated by the taurine transporter SLC6A6.
The exact molecular mechanism of either regulation is not known yet.
Variation can be due to either regulation by transcription factors or by epigenetic factors.
Such a role may be through either regulation of cation levels or membrane properties or both.
Meanwhile, the data-dependent network analysis of the γH2AX interactome revealed connectivity among multiple proteins known to be associated with either regulation of p53, cell cycle, or apoptosis (Supplementary Figure S3 and Supplementary Table S2), suggesting that all of the pathways represented by these γH2AX-docking proteins are interconnected.
We believe that these two mechanisms work independently because we saw only a marginal delay in spindle formation either in the mts3.1 proteasome mutant, hrs1.T14A stabilized mutant, or in the hrs1.FA6 nonphosphorylatable mutant, presumably because, when one of either regulation (degradation or phosphorylation) is missing, the remaining regulation still turns off the Hrs1 function.
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Successful global investment doesn't happen if one takes a cavalier attitude toward either regulations or to the formalities of proper business management.
The evidence that leads to either regulations or judicial decrees is affected by uncertainty and limited knowledge, raising difficult policy issues that we enumerate and discuss.
Under the policy, hospitals "could run afoul of either federal regulation or state regulation," said Kenneth E. Raske, president of the Greater New York Hospital Association, which encompasses the metropolitan area.
Therefore, our method can be used to obtain miRmR modules that represent either direct regulation or indirect regulation of mRNAs.
Genes or proteins may show random behavior without a clear indication of either down regulation or up regulation.
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