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10 We have recently observed this phenomenon in a different model, referring to MAT as either regulated or constitutive, and are actively working to define its molecular basis.
Indeed, similar TU distributions among the 5 classes defined above were observed for B. aphidicola TUs including genes with orthologues which are either regulated or un-regulated in E. coli, (Additional File 12).
Ongoing research indicates that countries with either regulated or legalized sex work have seen substantial falls in the prevalence of STIs in sex workers, as a result of governments' initiatives for wide-spread condom programs and promotion of HIV testing and treatment [ 59, 60].
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They are found either up regulated or down regulated in different cancers.
In other words, which of the many TORC1-controlled processes that are either up regulated or down regulated upon nutrient deprivation (TORC1 inactivation) leads to longer life?
The majority of genes involved in purine biosynthesis were either down regulated or unaffected following expression of DX; and purR, the repressor of purine biosynthesis, was up-regulated.
As a control of parasites synchronization, the relative expression of genes well known to be either strongly regulated or constitutively expressed during the intraerythrocytic cycle was determined.
p53 is a tumor suppressor and its expression is either down regulated or the protein is mutated in about 60% of advanced cancer cells [35], whereas p66Shc protein level is elevated in several types of cancers [5], [14], [15], [16].
This suggests that expression of prep1.1 is either auto-regulated, or regulated by one of its partners or paralogs (Pbx or Meis) whose dimers can bind the same sequences.
From fig 3, it could be suggested that some TF families preferentially regulate either up-regulated or down-regulated genes.
Moreover, most microbial surface components recognizing adhesive matrix molecules (MSCRAMMs) and cell-wall anchor family proteins [86] including the endocarditis- and biofilm-associated pilus (ebp) [87], [88] were either down-regulated, or not differential regulated (Table S1).
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