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Distinct immune infiltrates can either impair the metastatic process or conversely, assist in the seeding, colonization and growth of disseminated cancer cells.
The ultimate objective is to identify new treatment strategies, which could either impair robustness against stimuli or outsmart compensatory survival mechanisms.
This can partly be explained by the role of high dose steroids on CSF dynamics and vascular endothelium: steroid treatment has a paradoxical effect on CSF absorption and can either impair or facilitate its absorption.
Most alpha subunit mutations that have been studied to date either impair proreceptor processing and thus cell surface expression of mature receptors, or severely affect insulin binding to the receptor [ 4, 7].
There are series of drugs that either impair or facilitate fracture repair (Aspenberg 2005, Pountos et al. 2008).
Acute and chronic stress can both induce anxiety (McEwen and Gianaros 2011) and either impair learning and memory performance (Diamond et al. 1999; Nijholt et al. 2004) or enhance it (Blank et al. 2002).
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RESULTS: Carbohydrate intolerance (either impaired fasting glucose, impaired glucose tolerance, or both) was identified in 8.0%, near-diabetes (1 fasting glucose > or = 126 mg/dL [7.0 mmol/L] and/or 2-hour glucose > or = 200 mg/dL [11.1 mmol/L]) in 0.3%, and diabetes in 0.36% (type 1A = 0.24%; type 2 = 0.08%; undiagnosed type 2 = 0.04%).
A restricted number of genes showed either impaired variation when compared with control cells (clusters b and d) or variation restricted to cells with low levels of HP1γ (Figure 5B, cluster e), but their analysis did not reveal any convergent function.
These results suggest that ethanol either impairs the clearance of autophagosomes or affects authophagic catabolism.
However, although several mutations either impaired or enhanced ATP binding, there was no correlation between the disease phenotypes and the ATP-binding phenotype.
This evidence suggests that knockdown of IL13Rα2 either impairs extravasation of MIV cells in the lungs, or reduces survival in the circulation, or suppresses the colonization of secondary organs.
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CEO of Professional Science Editing for Scientists @ prosciediting.com