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In populations of African descent, CASPASE-12 is either functional or non-functional.
Generally, pancreatic neuroendocrine tumors are classified as either functional or non-functional depending on their ability to secrete biologically active hormones.
In particular, it offers an explanation as to why TFBSs with very similar properties may appear to be either functional or non-functional in different contexts.
We also saw that some gene segments reported to have both functional and non-functional alleles consistently behaved in our cohort as either functional or non-functional, suggesting that some reported alleles were not present in the population studied.
Due to the definite specification of Ago binding sites, we were able to classify miRNA recognition elements contained in the mRNA 3′UTR as either functional or non-functional.
The miR-mRNA pairs from the interactions set are reported in a binary format, as being either functional or non-functional, and we use the area under the ROC curve (AUC) measure to evaluate the sensitivity and specificity of our prediction method.
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To determine if GJIC was necessary for Cx43-linked increase in diapedesis and, more specifically, if heterocellular GJIC was necessary between tumor and endothelial cells, we compared diapedesis of HBL100 cells that expressed either the functional or non-functional Cx43 (GFP-Cx43).
Hence extensive polymorphism in the mutS rpoS region is postulated to result from cycling between environments in which the functional or non-functional genes provide distinct fitness advantages.
Tracers were classified as functional or non-functional based on their utility in vivo for reliable quantification of specific target binding.
We suspect that conditional exons can be divided into two groups: functional or non-functional exons.
Importantly, this method does not attempt to characterize differences as functional or non-functional, nor does it seek to identify key single point mutations.
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