Either deficiency implies a higher mutation rate and consequently a greater risk of cancer.
Either deficiency of normal heterotrimers or presence of mutant heterotrimers could lead to compromised basement membranes that perturb cell matrix signaling via cell surface receptors or growth factor-mediated cell cell signaling.
Either subclinical deficiencies of vitamin B6 or a genetic defeat on kynureninase can lead to the accumulation of xanthurenic acid (XA) in plasma and urine [ 5– 7].
However, some individuals are affected by abnormalities in GH secretion, which involve either deficiency or overabundance of the hormone.
Fluoride is considered as an essential element though health problems may arise from either deficiency or excess amount (Gopal and Gosh 1985).
Naturally occurring major, minor and trace elements in groundwater can have a significant effect on human and animal health through either deficiency or toxicity due to excessive intake (Frengstad et al. 2001).
It is plausible that a U-shaped dose response curve exists where either deficiency or supraphysiological doses may cause harm.
IFALD is also caused by either deficiency or excess of amino acids and lipids in PN solutions.
Animal and human studies have shown that adverse health effects may result from either deficiency or excess of Mn.
Except for hyperproliferation in keratinocytes, no other clinical conditions caused by either deficiency of overexpression of FABP5 have been reported so far in humans.
