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Cross-reactive immunity can have either advantageous or negative (e.g., leading to pathology) consequences.
Considering the ~30-fold fitness recovery in this strain [ 26], the identified GVs are expected to be either advantageous or neutral in this genetic background.
29, 78 Depending on the type of therapeutic being delivered and the intended target area of the tumor, this can be either advantageous or not.
Here, we examine the evolution of an increased mutation rate in a growing population of tumour cells, taking into account that additional mutations can be either advantageous or deleterious for the newly generated clone.
Consistent with the fitness recovery observed in this strain, rather than a decline in fitness, the mutation spectrum reported here reflects variants that are either advantageous or neutral in this specific genetic background.
Depending on the nature of the pathogen and the signal properties of the receptors, it is clear that pathogen-receptor interaction may be either advantageous or detrimental for the host, and as such, may rapidly change the ratio of activating versus inhibitory receptors, as well as their respective amount and specificities.
Similar(53)
Selection reflects a variation conferring either an advantageous or a deleterious fitness on individuals.
Depending on the use-case of the precoder, this change can either be advantageous or disadvantageous (see Fig. 1 and Subsection 4.2).
Missense mutations in structural genes may become either selectively advantageous or disadvantageous to the organism by affecting protein stability and/or interfering with interactions between partners.
Distributions of frequencies of ancestral alleles are also similar at polymorphic sites of recent nonsynonymous and synonymous allele replacements in human nuclear genes (fig. 3 b and c ), which is consistent with the assumption that nonsynonymous replacements were either strongly advantageous or neutral.
In the test proposed here, this proportion is estimated, assuming that a nonsynonymous replacement can be either strongly advantageous or neutral, as β = 1 − pn/ ps, where pn (ps) is the proportion of sites, among those nonsynonymous (synonymous) sites at which a nucleotide replacement occurred in the past, which currently carry both the derived and the ancestral nucleotides (fig. 1 b ).
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