Interesting technical practices included the use by the Romans of the semicircular arch in constructing moles or breakwaters, an arrangement that allowed a measure of ingress and egress by the sea to produce a beneficial scouring action in the harbour.
As nutrients become limited the pathogen switches to TP resulting in an overall metabolic slow down as the bacterium prepares for host cell egress by biosynthesis and assembly of flagella [5].
Core cells egress by extending protrusions which penetrate the apical cell-cell adhesions, and then undergoing amoeboid movements that translocate the cell body into the epithelium where cells become spindle-shaped and centripetally aligned (Figure 2A and Video S3 green cell).
Thus, barriers that limit molecular egress by lateral diffusion can define signaling domains that restrict enzymatic reactions to subregions of the cell surface.
Simplistically, two broad mechanisms of protease action may be imagined; proteases may act as indirect regulators of egress by activating distinct effector proteins or signal transduction pathways.
We here show that the P. falciparum perforin PPLP2 is crucial for RBC egress by activated gametocytes, but not by merozoites during blood stage schizogony.
