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Examples of good practices and the wish for collaborative efforts identified several common areas for progress (Table 4).
These efforts identified a series of novel, noncovalent FAAH inhibitors with in vitro potency comparable to known covalent FAAH inhibitors.
Our efforts identified compound 10b, which represents the lead compound in this series with pharmacokinetics and antiviral potency that may support once-daily dosing.
Screening efforts identified 1,2-dihydro-3-isoquinolone 1; however, this compound has the drawbacks of being difficult to synthesize with two asymmetric carbons on an isoquinolone scaffold and of having a highly lipophilic physicochemical property.
Screening efforts identified (bis)sulfonic acid, (bis benzamides (1 3) as compounds that interact with the follicle stimulating-hormone receptor (FSHR) and inhibit FSH-stimulated cAMP accumulation with IC50 values in the low micromolar range.
The pharmacophore model provided a minimum structural motif of Cdc7 inhibitor, by which preliminary medicinal chemistry efforts identified a dihydrothieno[3,2-d]-pyrimidin-4(1H -one scaffold having a heteroaromatic hinge-binding moiety.
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These efforts identify two genes, BRCA1 and BRCA2, each clearly associated with an increased incidence of ovarian cancer.
Facebook spokesman Jesse Baker responded to a VICE News interview request about the company's efforts identify fake news with a brief statement about the satire tag.
Using the OSD analysis to identify ancestrally different haplotypes allows us to focus initial efforts identifying causal genes for the QTL in the LH rat.
Her strategy worked, and the joint effort identified the gene.
Public health officials tracked its origins to China's southern provinces and, through a remarkable investigative effort, identified Johnny Chen's principal contacts.
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