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Our structure-guided optimization efforts considered also PDK1 X-ray structures with weaker binding fragments and resulted in 7-azaindoles with significantly improved biochemical PDK1 potency in the two-digit nanomolar range.
This modification is without practical efforts, considered the wide availability of software to compute spline bases.
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The chief justice was particularly grateful for Mather's painstaking efforts, "considering the place that I hold in the Court of Oyer and Terminer, still laboring and proceeding in the trial of the persons accused and convicted for witchcraft".
The existing research efforts consider only internode distances while modeling sensor data correlation [33].
If you do not have significant traction you need to redouble your marketing efforts, consider a Plan B or set some tangible milestones which you need to achieve to justify continuation of your business.
Consequently this review points out the need for more fundamental and deeper research efforts considering that heterogeneous (both gas-liquid and gas-liquid-solid) systems have an increasing industrial appeal.
Though some research efforts consider a fixed λ of 10 Hz [10], we motivate in [8] that generation rate adaptation as a network layer mechanism is one of the instruments to make beaconing more scalable.
FB: If you are doing your own publicity efforts, consider developing an ongoing dialogue and relationship with the bloggers that cover your genre and niche.
In an attempt to maximize prediction sensitivity, some efforts consider many interactions that lack a canonical 7 8 nt 3′-UTR site.
His largely forgotten effort considered the battle's forgotten survivors, who, "limping and lean and forlorn," had inherited from their country nothing but shell shock, pained deformity, and crippling unemployment.
Perhaps Tiger Woods could chip in on the effort, considering Forbes magazine just proclaimed him the first billion-dollar athlete.
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CEO of Professional Science Editing for Scientists @ prosciediting.com