Sentence examples for effort to develop potent from inspiring English sources

Different benzylidene derivatives (15a-o and 16a-o) of betulinic acid were designed and synthesized in an effort to develop potent anticancer agents.

In our effort to develop potent anti-hyperglycemic agents with potential agonistic activities toward PPARγ and SUR, three novel series of quinoxaline derivatives bearing sulfonylurea or sulfonylthiourea moieties with different linkers were designed and synthesized.

In an effort to develop potent anti-inflammatory and antithrombotic drugs, a series of new 4- 2-phenyltetrahydrofuran-3-yl) benzene sulfonamide analogs were designed and docked against homology models of human cyclooxygenase-2 (COX-2), lipoxygenase and thromboxane synthase enzymes built using MODELLER 7v7 software and refined by molecular dynamics for 2 ns in a solvated layer.

In an effort to develop potent cell adhesion molecule inhibitors, a series of chromone derivatives bearing alkoxycarbonylvinyl unit at the C-3 position, that is, the chromones 8a d and 9a d, were designed and synthesized, and evaluated for their ICAM-1 inhibitory activity on human endothelial cells as well as their effect on NADPH-catalyzed rat microsomal lipid peroxidation.

In our effort to develop potent and effective agents with anti-proliferative activity towards HepG2 hepatocellular carcinoma cells with potential inhibitory activity against VEGFR-2, a novel series of 1- 4- 2-oxoindolin-3-ylidene 1- 4- 2-oxoindolin-3-ylidene 1- 4- 2-oxoindolin-3-ylidene 1- 4- 2-oxoindolin-3-ylidene 1- 4- 2-oxoindolin-3-ylidene 1- 4- 2-oxoindolin-3-ylidene

These compounds form the foundation for further investigation in our continuing efforts to develop potent anticancer agents.

A novel series of 2-aminothiazole-oxazoles was designed and synthesized as part of efforts to develop potent phosphoinositide 3-kinase γ (PI3Kγ) inhibitors.

In this study, as a part of our ongoing efforts to develop potent T-type channel channel blockers, we designed oxazole derivatives substituted with arylpiperazinylalkylamines.

During the course of our research efforts to develop potent and selective AKT inhibitors, we discovered enatiomerically pure substituted dihydropyridopyrimidinones (DHP) as potent inhibitors of protein kinase B/AKT with excellent selectivity against ROCK2.

In continuing efforts to develop potent anti-inflammatory steroids without systemic adverse effects, methyl 9α-fluoro-11β,17α,21-trihydroxy-3,20-dioxo-pregna-1,4-diene-16α-carboxylate (FP16CM) and its 16-alkoxycarbonyl derivatives (FP16CE, FP16CP and FP16CB) were synthesized based on the antedrug concept.

The growing evidence in support of the correlation between CRL and cancer or other diseases leads to increased efforts to develop potent inhibitors.