Sentence examples for efflux without from inspiring English sources

However, we have introduced a modification that affords the evaluation of efflux without the need to centrifuge for the removal of EB.

In the case of MRP1, GSH might be effluxed along with another substrate, or it might stimulate substrate efflux without being transported.

These data demonstrate the pivotal role of STX1 in supporting DA efflux without altering forward transport of DA in brain tissues.

Chemomodulators belong to two categories, those that are transport substrates themselves and thereby compete for efflux and those that exert their effects by binding to and blocking drug efflux without themselves being transported out of the cell [ 24].

Macrophages, which were alternatively activated with IL-13 in vitro, have an increased capacity of clearing OxLDL by promoting its uptake as well as cholesterol efflux without increasing net foam-cell formation.

In the metabolic disorders investigated here all metabolites that were experimentally reported as accumulating could be effluxed without the need to alter these constraints.

Therefore, the reversal of MRP7-mediated MDR by PD173074 in HEK293-MRP7 cells involved direct inhibition of MRP7 efflux function without interfering MRP7 protein expression.

In conclusion, here we report for the first time that WHI-P154 could significantly reverse wild-type and mutant ABCG2-mediated MDR by inhibiting the efflux function without affecting expression level or localization of ABCG2.

Taken together, our data demonstrate that macrophages alternatively activated by IL-13 have an overall increased capacity of OxLDL clearance, as they display increased uptake as well as increased cholesterol efflux capacities without enhancing foam-cell formation.

Furthermore, all four C2 sublines showed minimal functional P-gp as measured by rhodamine efflux with or without administration of the P-gp inhibitor, verapamil.

In the rat pilocarpine model of epilepsy, increased brain concentration of the active metabolite of oxcarbazepine was observed following seizures together with inhibition of BBB efflux transport, but without changes in plasma concentrations.